| Product Name | PARN Antibody (H-105) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 408-512 mapping within an internal region of PARN of human origin |
| Modification Notes | Exonucleolytic degradation of the poly(A) tail often initiates the first step in the decay of eukaryotic mRNAs. Poly(A)-specific ribonuclease (PARN), a highly poly(A)-specific 3'-exoribonuclease, efficiently degrades mRNA poly(A) tails. PARN, which also may be designated deadenylating nuclease, may also be involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons, and in the degradation of inherently unstable mRNAs that contain au-rich elements (AREs) in their 3' untranslated regions. PARN, which can form a homodimer, interacts with KHSRP and can be found in a mRNA decay complex with RENT1, RENT2 and RENT3B.It localizes mainly to the nucleus (may be detected in the nucleolus), but may also localize to the cytoplasm. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PARN of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 408-512 mapping within an internal region of PARN of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 408-512 mapping within an internal region of PARN of human origin |
| Entrez Gene | 5073 |
|---|
| Application Notes | recommended for detection of PARN of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
