| Product Name | SLPI Antibody (H-88) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 13-100 mapping within an internal region of SLPI of human origin |
| Modification Notes | SLPI, secretory leukocyte protease inhibitor, is an enzyme that belongs to the å-1 antitrypsin antiprotein family. Produced by epithelial cells, SLPI resides in parotid secretions, bronchial, nasal and cervical mucus, and seminal fluid. SLPI plays a primary role in the regulation of neutrophil-mediated inflammation. It does so through proteolysis and subsequent inhibition of the leukocyte serine proteases, including the neutrophil and pancreatic proteases. The promoter region of SLPI has been identified as binding site for IRF-1, interferon regulatory factor. Expression of SLPI is inhibited by IRF-1 co-expression, identifying SLPI as a target of IRF-1 regulation. SLPI also functions as a macrophage derived inhibitor of macrophage response to LPS by inhibiting the production of nitric oxide, which suggests the role of SLPI in LPS tolerance. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of precursor and mature forms of SLPI of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 13-100 mapping within an internal region of SLPI of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 13-100 mapping within an internal region of SLPI of human origin |
| Entrez Gene | 6590 |
|---|
| Application Notes | recommended for detection of precursor and mature forms of SLPI of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
