| Product Name | Na+ CP type IIα Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 281-330 mapping near the N-terminus of Na+ CP type IIα of human origin |
| Modification Notes | Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming å subunit, a noncovalently associated ∫1 subunit and a disulfide-linked ∫2 subunit. The two ∫ subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The å subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIå subunits are more abundant along axons. The ∫1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, ∫1 and ∫2 are highly expressed in Purkinje cells, and ∫1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Na+ CP type IIα of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 281-330 mapping near the N-terminus of Na+ CP type II&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 281-330 mapping near the N-terminus of Na+ CP type IIα of human origin |
| Entrez Gene | 6326 |
|---|
| Application Notes | recommended for detection of Na+ CP type IIα of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
