Application
Western blot analysis of NARC-1 expression in non-transfected: (A) and mouse NARC-1 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of NARC-1 expression in rat intestine tissue extract.| Product Name | NARC-1 Antibody (H-160) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 175-334 mapping within an internal region of NARC-1 of human origin |
| Modification Notes | Proprotein convertase subtilisin/kexin type 9 (NARC-1) belongs to the peptidase S8 family. NARC-1, a secreted protein, is important in cortical neuron differentiation and in cholesterol homeostasis. NARC-1 dramatically impairs the expression of the low density lipoprotein receptor (LDLr) and, in turn, LDL cellular binding and LDL clearance from the plasma compartment. NARC-1 is expressed in Shwann cells, colon carcinoma, neuro-epithelioma and hepatic and pancreatic cell lines. Defects in the gene encoding this protein cause the autosomal dominant disorder familial hypercholesterolemia 3 (FH3). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NARC-1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 175-334 mapping within an internal region of NARC-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 175-334 mapping within an internal region of NARC-1 of human origin |
| Entrez Gene | 255738 |
|---|
Application
Western blot analysis of NARC-1 expression in non-transfected: (A) and mouse NARC-1 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of NARC-1 expression in rat intestine tissue extract.| Application Notes | recommended for detection of NARC-1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
