| Product Name | PI 4-kinase β Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of I 4-kinase β of human origin |
| Modification Notes | The members of the phosphatidylinositol kinase (PIK) superfamily can be divided into three groups based on their substrate specificity. PIKs convert phosphatidylinositol (PI) into PI phosphate [PI(3)P], PI phosphate [PI(4)P], PI bisphosphate [PI(4,5)P2] and PI triphosphate [PI(3,4,5)P3]. The first group, the PI 3-kinases, is composed of highly related proteins designated p110å, p110∫, p110© and p110∂ which convert PI into PI(3)P and PI(4,5)P2 into PI(3,4,5)P3. The second group, the PI 4-kinases, convert PI into PI(4)P. The third group, the PI(4)P5-kinases, convert PI(4)P into PI(4,5)P2. Phosphatidylinositides represent important regulatory molecules and are involved in a diverse array of signaling pathways. Phosphatidylinositol biphosphate acts as an activator of PKCs and as a substrate for PLC ©, which converts the molecule into the second messengers, Inositol-1,4,5 triphosphate and 1,2-diacylglycerol. PI(3,4,5)P3 has been shown to activate the PKC Ω isoform. PI 4-kinase ∫ is a cytoplasmic protein inhibited by Wortmannin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of I 4-kinase β of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of I 4-kinase &beta of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of I 4-kinase β of human origin |
| Entrez Gene | 5298 |
|---|
| Application Notes | recommended for detection of I 4-kinase β of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
