Application
Western blot analysis of Retinal RX expression in non-transfected: (A) and mouse Retinal RX transfected: (B) 293T whole cell lysates.Application
Western blot analysis of Retinal RX expression in non-transfected: (A) and mouse Retinal RX transfected: (B) 293T whole cell lysates.| Product Name | Retinal RX Antibody (H-120) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-120 mapping at the N-terminus of Retinal RX of human origin |
| Modification Notes | The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. Retinal RX, also known as RAX (retina and anterior neural fold homeobox), MCOP3 or RX, is a 346 amino acid protein that localizes to the nucleus and contains one OAR domain and one homeobox DNA-binding domain. Expressed in developing eye tissue, as well as in adult retina tissue, Retinal RX plays a crucial role in eye formation, specifically by regulating the specification and proliferation of retinal cells. Defects in the gene encoding Retinal RX are the cause of microphthalmia isolated type 3 (MCOP3), a heterogeneous disorder that is characterized by opacities of the cornea and lens and scaring of the retina and choroid. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Retinal RX of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-120 mapping at the N-terminus of Retinal RX of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-120 mapping at the N-terminus of Retinal RX of human origin |
| Entrez Gene | 30062 |
|---|
Application
Western blot analysis of Retinal RX expression in non-transfected: (A) and mouse Retinal RX transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of Retinal RX expression in non-transfected: (A) and mouse Retinal RX transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of Retinal RX of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
