Application
Western blot analysis of Dab1 phosphorylation in mouse brain (A) and rat brain (B) tissue extracts.| Product Name | p-Dab1 Antibody (Tyr 232) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Tyr 232 of Dab1 of human origin |
| Modification | Phosphoralated |
| Modification Notes | Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Thought to play a role in directing migrating neurons, Reelin is a secreted protein that requires tyrosine phosphorylation of Dab1 for its signaling activity. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Tyr 232 phosphorylated Dab1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Tyr 232 of Dab1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Tyr 232 of Dab1 of human origin |
| Entrez Gene | 1600 |
|---|
Application
Western blot analysis of Dab1 phosphorylation in mouse brain (A) and rat brain (B) tissue extracts.| Application Notes | recommended for detection of Tyr 232 phosphorylated Dab1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
