| Product Name | cubilin Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 3324-3623 mapping at the C-terminus of cubilin of human origin |
| Modification Notes | Cubilin is an endocytic receptor that lacks a classical transmembrane region (1). It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains (2). The gene encoding human cubulin maps to chromosome 10 and it is predominantly expressed in intestine, kidney and yolk sac (1–3). It also is expressed in intestinal membranes (2). Cubilin colocalizes with and binds to megalin, a member of the LDL receptor family that is required for the internalization of cubulin-bound ligands, such as vitamin B12, apolipoprotein A1 and albumin (1,2,4,5). Megalin specifically binds to cubilin in the amino terminal region that contains the EGF-like repeats and CUB domains 1 and 2 (2). Mutations in the cubulin gene are thought to cause megaloblastic anemia 1 (MGA1), an autosomal recessive disorder also known as Imerslund-Grasbeck’s disease, which causes intestinal malabsorption of vitamin B12 (3,6,7). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of cubilin of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 3324-3623 mapping at the C-terminus of cubilin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 3324-3623 mapping at the C-terminus of cubilin of human origin |
| Entrez Gene | 8029 |
|---|
| Application Notes | recommended for detection of cubilin of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
