Application
Western blot analysis of HIS-tagged human recombinant TGFβ RII.| Product Name | TGFβ RII Antibody (H-567) FITC |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-567 representing full length TGFβ RII of human origin |
| Modification Notes | A total of three members of the TGF∫ family, TGF∫1, TGF∫2 and TGF∫3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGF∫s mediate their activity by high affinity binding to the type II receptor (TGF∫ RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. TGF∫ RII (TGF-beta receptor type-2), also known as TGFBR2, is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain and is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. For signaling growth inhibition and early gene responses, TGF∫ RII requires both its kinase activity and association with a TGF∫-binding protein, designated the type I receptor. TGF∫ RII exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TGFβ RII p70 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-567 representing full length TGF&beta RII of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-567 representing full length TGFβ RII of human origin |
| Entrez Gene | 7048 |
|---|
Application
Western blot analysis of HIS-tagged human recombinant TGFβ RII.| Application Notes | recommended for detection of TGFβ RII p70 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
