| Product Name | Angiomotin-L2 Antibody (H-40) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 595-634 mapping within an internal region of Angiomotin-L2 of human origin |
| Modification Notes | Angiomotin, also known as AMOT, is a 1,084 amino acid protein that belongs to the motin family of angiostatin binding proteins. Members of the motin family contain conserved coiled-coil domains and PDZ binding motifs at their C-termini. Expressed in skeletal muscle and placenta, Angiomotin localizes to the cell surface at tight junctions and is believed to be involved in tight junction maintenance. Angiomotin binds to angiostatin and plays a vital role in angiogenesis, promoting tubule formation and growth factor-induced migration of endothelial cells. This suggests that Angiomotin may be an important player in tumor angiogenesis and could serve as a potential therapeutic target in cancer. Angiomotin-L2, also known as AMOTL2 or LCCP, is a 779 amino acid protein that exists as multiple alternatively spliced isoforms and may function in a similar manner to Angiomotin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Angiomotin-L2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 595-634 mapping within an internal region of Angiomotin-L2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 595-634 mapping within an internal region of Angiomotin-L2 of human origin |
| Entrez Gene | 51421 |
|---|
| Application Notes | recommended for detection of Angiomotin-L2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
