| Modification Notes |
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. ZNF508 (zinc finger protein 508), also known as ADNP2 (ADNP homeobox 2), is a 1,131 amino acid protein that contains one homeobox DNA-binding domain and four C2H2-type zinc fingers. Localized to the nucleus, ZNF508 belongs to the krueppel C2H2-type zinc finger family and is thought to be involved in transcriptional regulation. The gene encoding ZNF508 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas. |