Application
Western blot analysis of Leiomodin 2 expression in mouse spleen (A) and rat skeletal muscle (B) tissue extracts.Application
Western blot analysis of Leiomodin 2 expression in mouse heart tissue extract.| Product Name | Leiomodin 2 Antibody (S-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of Leiomodin 2 of human origin |
| Modification Notes | Members of the Leiomodin protein family are closely related to the tropomodulin family of actin filament pointed end-capping proteins. Leiomodins are actin-binding proteins that act as strong filament nucleators in muscle cells. Leiomodin 1 is highly expressed in a variety of tissues that contain smooth muscle, therefore it is also known as smooth muscle Leiomodin, or SM-Lmod. Also designated C-Lmod, Leiomodin 3 is found in several types of fetal tissue and is involved in tropomyosin binding. Leiomodin 2, also known as C-LMOD or LMOD2, is a 547 amino acid protein that is specifically expressed in heart and skeletal muscles. Leiomodin 2 binds to tropomyosin and may block the elongation and depolymerization of actin filaments at their pointed end. Leiomodin 2 is encoded by a gene that is located near the hypertrophic cardiomyopathy locus CMH6 on chromosome 7, suggesting that Leiomodin 2 may be involved in that disease process. Leiomodin 2 is expressed as three alternatively spliced variants. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Leiomodin 2 isoforms 1-3 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with Leiomodin 1 or Leiomodin 3 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of Leiomodin 2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of Leiomodin 2 of human origin |
| Entrez Gene | 442721 |
|---|
Application
Western blot analysis of Leiomodin 2 expression in mouse spleen (A) and rat skeletal muscle (B) tissue extracts.
Application
Western blot analysis of Leiomodin 2 expression in mouse heart tissue extract.| Application Notes | recommended for detection of Leiomodin 2 isoforms 1-3 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with Leiomodin 1 or Leiomodin 3 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
