Application
Immunofluorescence staining of normal mouse intestine frozen section showing extracellular matrix staining.WB
(A): Immunohistochemical examination of aggrecan, Immunohistochemical examination of MMP13| Product Name | aggrecan Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Conjugation | Agarose |
| Modification | Acetylated |
| Modification Notes | The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage (1). Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican (2,3). Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification (4). Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network (5). Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage (1,5). Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage (5). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCIPWB |
| WB:1:100~1:500 IP:1:20~1:100 IF:1:20~1:100 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1911-1962 of aggrecan of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1911-1962 of aggrecan of human origin |
| Entrez Gene | 176 |
|---|
Application
Immunofluorescence staining of normal mouse intestine frozen section showing extracellular matrix staining.
WB
(A): Immunohistochemical examination of aggrecan, Immunohistochemical examination of MMP13| Application Notes | WB:1:100~1:500 IP:1:20~1:100 IF:1:20~1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
