| Product Name | C1r Antibody (H-126) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 188-313 mapping within an internal region of C1r of human origin |
| Modification Notes | The complement component proteins, C1, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the classical pathways of the serum complement system. C1 consists of a calcium dependent trimolecular complex of C1r, C1s and C1q in a 2:2:1 ratio. C1r is a dimer formed of two identical chains that are activated by cleavage into two chains, A and B. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of mature C1r, C1r heavy chain and C1r precursor of human and rat origin and C1ra and C1rb of mouse origin by WB, IP, IF and ELISA non cross-reactive with C1r light chain also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 188-313 mapping within an internal region of C1r of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 188-313 mapping within an internal region of C1r of human origin |
| Application Notes | recommended for detection of mature C1r, C1r heavy chain and C1r precursor of human and rat origin and C1ra and C1rb of mouse origin by WB, IP, IF and ELISA non cross-reactive with C1r light chain also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
