Application
Western blot analysis of human recombinant CDSN fusion protein.| Product Name | CDSN Antibody (H-80) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 281-360 mapping within an internal region of CDSN of human origin |
| Modification Notes | Corneodesmosin (CDSN), also designated S protein, is a secreted protein found in corneodesmosomes, the intercellular structures that are involved in desquamation and the shedding of superficial corneocytes from the skin surface. CDSN expression is only observed in skin and its expression is associated with susceptibility to psoriasis, a heterogeneous inflammatory skin disease. The gene encoding for corneodesmosin, CDSN, is a strong candidate gene for psoriasis susceptibility due to its exclusive expression in differentiating keratinocytes. The CDSN gene contains 2 exons which encode a presumed 486-amino acid protein, including a putative 16-amino acid signal sequence. The CDSN protein shows homology to Loricrin, Cytokeratin 1 and Cytokeratin 10, which are all major components of the granular layer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Corneodesmosin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 281-360 mapping within an internal region of CDSN of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 281-360 mapping within an internal region of CDSN of human origin |
Application
Western blot analysis of human recombinant CDSN fusion protein.| Application Notes | recommended for detection of Corneodesmosin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
