| Product Name | RGS18 Antibody (H-80) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-80 mapping at the N-terminus of RGS18 of human origin |
| Modification Notes | The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a subunits) thereby driving G proteins into their inactive GDP-bound form. RGS18 is a 234 amino acid peptide expressed mainly in megakaryocyte cells, but also in hemato-poietic progenitor and myeloerythroid lineage cells. RGS18 expression is upregulated during megakaryocyte differentiation and may play an important role in the mediation of megakaryocyte chemotaxis. Structurally, RGS18 contains phosphorylation sites for casein kinase II, protein kinase C and protein kinase A. RGS18 specifically binds to two a subunits of the G protein, Gai and Gaq. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of RGS18 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-80 mapping at the N-terminus of RGS18 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-80 mapping at the N-terminus of RGS18 of human origin |
| Entrez Gene | 64407 |
|---|
| Application Notes | recommended for detection of RGS18 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
