| Product Name | CARD 9 Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 98-187 mapping within an internal region of CARD 9 of human origin |
| Modification Notes | Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3), and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 9 is the main transducer of Dectin-1 signals that consist of mediated myeloid cell activation, cytokine production, and innate anti-fungal immunity. Dectin-1 is the main mammalian receptor that recognizes the fungal component zymosan. CARD 9 self-associates and has coiled-coil motifs that may function as oligomerization domains. Bcl10 interacts with CARD 9 and regulates the zymosan induced NF-˚B activation. Overexpression of CARD 9 correlates with the development of gastric B-cell lymphoma. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CARD 9 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 98-187 mapping within an internal region of CARD 9 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 98-187 mapping within an internal region of CARD 9 of human origin |
| Entrez Gene | 64170 |
|---|
| Application Notes | recommended for detection of CARD 9 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
