Application
Western blot analysis of DOC1 expression in non-transfected: (A) and human DOC1 transfected: (B) 293T whole cell lysates.| Product Name | DOC1 Antibody (C-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of DOC1 of human origin |
| Modification Notes | DOC1 (Down-regulated in Ovarian Cancer-1), also known as Filamin A-interacting protein 1-like and GPBP-interacting protein, is a 1135 amino acid protein that was originally cloned from normal ovarian epithelial cell lines, but was consistently found to be absent in ovarian cancer cell lines. Knockdown of DOC1 mRNA results in suppression of the EMAP II-stimulated gene expression of DOC1 as well as four other genes, suggesting that DOC1 may mediate the effect of EMAP II. The gene encoding DOC1 is upregulated in endothelial cells treated with angiogenesis inhibitors, which alludes to its potential benefit as a antivascular reagent for cancer therapy. There are five isoforms of DOC1 that exist as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DOC1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of DOC1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of DOC1 of human origin |
| Entrez Gene | 11259 |
|---|
Application
Western blot analysis of DOC1 expression in non-transfected: (A) and human DOC1 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of DOC1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
