Application
Western blot analysis of 3BP1 expression in non-transfected: (A) and mouse 3BP1 transfected: (B) 293T whole cell lysates.| Product Name | 3BP1 Antibody (D-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of 3BP1 of human origin |
| Modification Notes | 3BP1 (SH3 domain-binding protein 1) is a 701 amino acid protein with sequence similarity to the COOH-terminal segment of Bcr. This similarity suggests 3BP1 has GTPase-activating protein (GAP) activity for Rac-related proteins. 3BP1 also binds to the SH3 domains of signal transduction pathway proteins, with preference for SRC-1 and GRB2. 3BP1 has also been found to inhibit PDGF-induced membrane ruffling mediated by Rac. Expressed as two isoforms produced by alternative splicing, 3BP1 contains one BAR domain and one Rho-GAP domain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of 3BP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of 3BP1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of 3BP1 of human origin |
| Entrez Gene | 23616 |
|---|
Application
Western blot analysis of 3BP1 expression in non-transfected: (A) and mouse 3BP1 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of 3BP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
