Application
Western blot analysis of VRK2 expression in HeLa nuclear extract.Application
Western blot analysis of VRK2 expression in K-562 whole cell lysate.| Product Name | VRK2 Antibody (H-255) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 254-496 mapping at the C-terminus of VRK2 of human origin |
| Modification Notes | VRK2 (vaccinia related kinase 2) is a 508 amino acid single-pass type IV membrane protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Widely expressed with highest expression in heart, skeletal muscle, pancreas, testis and fetal liver, VRK2 is thought to function as a serine/threonine kinase that catalyzes the ATP-dependent phosphorylation of target proteins, such as casein and p53, thereby regulating their function within the cell. VRK2 is localized to the endoplasmic reticulum (ER) and, via its ability to regulate protein activity, is thought to be involved in normal cell proliferation events. Expression of VRK2 is upregulated in certain carcinomas, suggesting a possible role for VRK2 in carcinogenesis. Five isoforms of VRK2 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of VRK2 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 254-496 mapping at the C-terminus of VRK2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 254-496 mapping at the C-terminus of VRK2 of human origin |
| Entrez Gene | 7444 |
|---|
Application
Western blot analysis of VRK2 expression in HeLa nuclear extract.
Application
Western blot analysis of VRK2 expression in K-562 whole cell lysate.| Application Notes | recommended for detection of VRK2 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
