Application
Western blot analysis of RNase Z1 expression in PC-12 whole cell lysate.| Product Name | RNase Z1 Antibody (N-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the N-terminus of RNase Z1 of human origin |
| Modification Notes | RNase Z1 (Ribonuclease Z 1), also known as ELAC1 or D29, is a 363 amino acid nuclear protein that belongs to the RNase Z family of RNA-processing enzymes. Expressed throughout the body with highest expression in lung, brain, placenta, heart, liver, kidney and pancreas, RNase Z1 is a zinc phosphodiesterase that plays a role in tRNA maturation by removing 3'-trailer segments from precursor tRNA. In addition, RNase Z has a variety of other zinc-dependent RNA processing activities, including generation of 3' termini on tRNA, endonucleolytic cleavage of RNA and removal of extra 3' nucleotides from unprocessed tRNA. Defects in the gene encoding RNase Z1 may be involved in the pathogenesis of prostate cancer, suggesting a possible role for RNase Z1 in carcinogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of RNase Z1 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other RNase family members also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the N-terminus of RNase Z1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the N-terminus of RNase Z1 of human origin |
| Entrez Gene | 55520 |
|---|
Application
Western blot analysis of RNase Z1 expression in PC-12 whole cell lysate.| Application Notes | recommended for detection of RNase Z1 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other RNase family members also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
