| Product Name | p-MEK kinase-1 Antibody (Thr 1402) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Thr 1383 phosphorylated MEK kinase-1 of human origin by WB, IP and ELISA |
| Modification | Phosphoralated |
| Modification Notes | Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4, ASK 1 (MEK kinase-5) and MAP3K6 (MEK kinase-6). MEK kinase-1 activates the ERK and c-Jun NH(2)-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NF˚B pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination. MEK kinase-1 is autophosphorylated at two C-terminal sites within the activation loop, Thr 1402 and Thr 1414, following oligomerization. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| See 1 citations for p-MEK kinase-1Antibody (Thr 1402): |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Thr 1383 phosphorylated MEK kinase-1 of human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of Thr 1383 phosphorylated MEK kinase-1 of human origin by WB, IP and ELISA |
| Entrez Gene | 4214 |
|---|
| Application Notes | See 1 citations for p-MEK kinase-1Antibody (Thr 1402): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
