SLC39A12 (solute carrier family 39 (zinc transporter), member 12), also known as ZIP12 (Zrt- and Irt-like protein 12) or LZT-Hs8 (LIV-1 subfamily of ZIP zinc transporter 8), is a 691 amino acid multi-pass membrane protein that belongs to the LIV-1 subfamily of the ZIP family (or SLC39 family) of metal transporters. In humans, there are at least fifteen members of the ZIP family, all of which exhibit unique tissue-specific expression and are involved in zinc transport and metabolism. Members of the LIV-1 subfamily share similarity with the estrogen-regulated protein LIV-1 and contain a distinct motif with conserved glutamic acid and proline residues. Expressed in brain and eye tissues, SLC39A12 is believed to function as a zinc transporter, facilitating zinc influx into the cytosol. In addition, SLC39A12 may play a role in the onset of schizophrenia. Due to alternative splicing events, four SLC39A12 isoforms are produced.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of SLC39A12 of human origin by WB, IP and ELISA: