Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF91, also known as PZF or FKSG11, is a member of the Krüppel C2H2-type zinc-finger family of transcriptional regulators. Localized to the nucleus, ZNF91 is expressed ubiquitously, with particularly high levels in testis. Two isoforms (namely isoform 1 and isoform 2) of ZNF91 exist as a result of alternative splicing events, and isoform 2 is testis-specific. ZNF91 has been identified to play a role in transcriptional regulation, cell proliferation and anti-apoptotic events.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of ZFP91 of human origin by WB, IP and ELISA: