Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing nuclear and cytoplasmic staining of glandular cells.Application
Western blot analysis of ERRβ expression in non-transfected: (A) and human ERRβ transfected: (B) 293T whole cell lysates.| Product Name | ERRβ/γ Antibody (H-66) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 251-316 mapping within an internal region of ERR β of human origin |
| Modification Notes | Estrogen and progesterone receptors are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. Estrogen receptor-related proteins (ERRå, ∫ and ©) are orphan nuclear receptors. Like estrogen receptors, ERRs bind specifically to EREs to activate reporter genes. ERR∫, also known as steroid hormone receptor ERR2 or estrogen receptor-like 2, is expressed during mammary gland development and is critical in embryo development. The loss of ERR∫ results in severely impaired chorion formation leading to placental failure and embryonic death. ERR∫ also potently represses the transcriptional activity of Nrf2. ERR©, also known as ERR3, is abundantly expressed in fetal heart. The loss of ERR© results in lactatemia and death within the first week of life. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ERRβ and ERRγ of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 251-316 mapping within an internal region of ERR &beta of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 251-316 mapping within an internal region of ERR β of human origin |
| Entrez Gene | 2103 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing nuclear and cytoplasmic staining of glandular cells.
Application
Western blot analysis of ERRβ expression in non-transfected: (A) and human ERRβ transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of ERRβ and ERRγ of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
