| Product Name | TIF1γ Antibody (H-106) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 571-676 mapping within an internal region of TIF1γ of human origin |
| Modification Notes | Transcriptional intermediary factor 1-å (TIF1å) mediates transcriptional events by interactions with the AF2 region of several nuclear receptors, such as the estrogen, retinoic acid, and vitamin D3 receptors. TIF1å localizes to nuclear bodies and is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains (RING, B-box type 1 and B-box type 2) and a coiled-coil region. TIF1∫ is also a member of the TRIM family that contains both a Cys/His PHD finger and bromodomain that form a cooperative unit required for transcriptional repression. TIF1∫ mediates transcriptional control by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors and by binding DNA via its zinc finger. TIF1© has a similar structure to the previous two TRIM members, though it presents several functional differences. TIF1© interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGF∫. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of transcription intermediary factor 1γ of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 571-676 mapping within an internal region of TIF1&gamma of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 571-676 mapping within an internal region of TIF1γ of human origin |
| Entrez Gene | 51592 |
|---|
| Application Notes | recommended for detection of transcription intermediary factor 1γ of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
