| Modification Notes |
Composed of more than eleven subunits, the anaphase-promoting complex (APC), also known as the cyclosome, acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. The APC accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. The APC is phosphorylated, and thus activated, by protein kinases Cdk1, cyclin B and polo-like kinase (Plk) and is under tight control by a number of regulatory factors, including p55 CDC, cadherin and MAD2. APC13 (Anaphase-promoting complex subunit 13), also known as ANAPC13 or SWM1, is a 74 amino acid nuclear protein that functions as a component of the APC complex. |