Application
Western blot analysis of MOAP1 expression in non-transfected: (A) and mouse MOAP1 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of MOAP1 expression in non-transfected: (A) and human MOAP1 transfected: (B) 293 whole cell lysates.| Product Name | MOAP1 Antibody (M-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 303-352 mapping at the C-terminus of MOAP1 of mouse origin |
| Modification Notes | MOAP1 (modulator of apoptosis 1) is a 352 amino acid protein encoded by the human gene MOAP1. MOAP1 belongs to the PNMA family and contains one BH3-like domain and one RASSF1-binding domain. It is required for death receptor-dependent apoptosis. When MOAP1 is associated with RASSF1, it promotes a Bax conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. MOAP1 is a homo-dimer and, under normal circumstances, is held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to Bax. MOAP1 will also bind to Bcl-2 and Bcl-x. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MOAP1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 303-352 mapping at the C-terminus of MOAP1 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 303-352 mapping at the C-terminus of MOAP1 of mouse origin |
| Entrez Gene | 64113 |
|---|
Application
Western blot analysis of MOAP1 expression in non-transfected: (A) and mouse MOAP1 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of MOAP1 expression in non-transfected: (A) and human MOAP1 transfected: (B) 293 whole cell lysates.| Application Notes | recommended for detection of MOAP1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
