Application
Western blot analysis of SMPDL3B expression in non-transfected: (A) and mouse SMPDL3B transfected: (B) 293T whole cell lysates.| Product Name | SMPDL3B Antibody (M-76) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 196-271 mapping within an internal region of SMPDL3B of mouse origin |
| Modification Notes | SMPDL3B (sphingomyelin phosphodiesterase, acid-like 3B), also known as ASMLPD or ASML3B (Acid sphingomyelinase-like phosphodiesterase 3B), is a 455 amino acid secreted protein belonging to the acid sphingomyelinase family. It is expressed in granulosa cells of the ovarian follicle and is a homolog of ASM (acid sphingomyelinase). ASM is a lysosomal protein that hydrolyzes sphingomyelin to ceramide and phosphocholine playing an important role in apoptosis of germ cell lines. Deficiency of ASM is associated with type A and type B Niemann-Pick disease. Type A is a fatal neurodegenerative disorder seen in infancy and resulting in death by age three, whereas type B is a non-neuropathic disease with a later onset. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SMPDL3B of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 196-271 mapping within an internal region of SMPDL3B of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 196-271 mapping within an internal region of SMPDL3B of mouse origin |
| Entrez Gene | 27293 |
|---|
Application
Western blot analysis of SMPDL3B expression in non-transfected: (A) and mouse SMPDL3B transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of SMPDL3B of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
