| Product Name | Oatp2 Antibody (M-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 611-660 mapping near the C-terminus of Oatp2 of mouse origin |
| Modification Notes | The organic anion transporting polypeptides, Oatp2 (also designated Slc21a5 and Slco1a4) and OATP-C (also designated LST-1, OATP2, OATP1B1 and SLC21A6), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. Oatp2, which is expressed in liver and brain, helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and localized to the basolateral hepatocyte membrane. Although OATP-C mRNA levels decrease during pregnancy and increase postpartum, OATP-C protein levels remain relatively constant. Oatp2 transports taurocholic acid, the adrenal androgen dehydroepiandroserone sulfate, thyroid hormone, hydroxymethylglutaryl-CoA reductase inhibitor and pravastatin. Oatp2 and OATP-C are both pravastatin transporters, suggesting that they are responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Oatp2 of mouse origin and, to a lesser extent OATP and OATK family members of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 611-660 mapping near the C-terminus of Oatp2 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 611-660 mapping near the C-terminus of Oatp2 of mouse origin |
| Entrez Gene | 28250 |
|---|
| Application Notes | recommended for detection of Oatp2 of mouse origin and, to a lesser extent OATP and OATK family members of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
