| Modification Notes |
PRELI (protein of relevant evolutionary and lymphoid interest), also known as PRELID1, is a 219 amino acid mitochondrial protein that is encoded within a conserved I˚B-å and Rab 24 gene cluster. PRELI is highly expressed in fetal liver, which is a major site for B cell lymphopoiesis. During maturation, expression levels of PRELI are drastically reduced in liver and predominant expression is found in brain, lymph nodes, peripheral blood leukocytes and spleen. Changes in expression pattern suggest that PRELI is vital for the development of immunocompetent organs. PRELI contains a late embryogenesis abundant (LEA) motif which is commonly found in plant proteins, suggesting a phylogenetic link between plants and animals. PRELI also contains a 170 amino acid PRELI/MSF1 domain at its N-terminus which may have a function associated with the cellular membrane. |