| Product Name | ARH Antibody (H-119) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 74-192 mapping within an internal region of ARH of human origin |
| Modification Notes | ARH (autosomal recessive hypercholesterolemia protein), also known as LDLRAP1 (low density lipoprotein receptor adapter protein 1), is a 308 amino acid cytoplasmic protein that contains one PID domain. ARH is an adapter protein required for efficient endocytosis of the LDL receptor (LDLR) from coated pits in polarized cells such as hepatocytes and lymphocytes. To do this, ARH acts to stabilize the interaction between the receptor and the structural components of the pits. While expressed at high levels in kidney, liver and placenta, ARH is expressed at low levels in brain, heart, muscle, colon, spleen, intestine, lung and leukocytes. Defects in the ARH gene are the cause of autosomal recessive hypercholesterolemia, a disorder caused by defective internalization of LDL receptors (LDLR) in the liver. Autosomal recessive hypercholesterolemia has the clinical features of familial hypercholesterolemia (FH), including severely elevated plasma LDL cholesterol, tuberous and tendon xanthomata, and premature atherosclerosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ARH of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 74-192 mapping within an internal region of ARH of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 74-192 mapping within an internal region of ARH of human origin |
| Entrez Gene | 26119 |
|---|
| Application Notes | recommended for detection of ARH of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
