| Product Name | CCM3 Antibody (H-189) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 3-191 mapping within an internal region of CCM3 of human origin |
| Modification Notes | Programmed cell death (apoptosis) of nonessential cells is necessary for embryogenesis, metamorphosis, tissue turnover and proper development and function of the immune system. CCM3, also known as Pdcd-10, is a member of the family of programmed cell death proteins that regulate apoptotic pathways. CCM3 is and anti-apoptotic protein that is essential for proper vascular development and maturation. Through direct interaction with and positive regulation of MST4 in the ERK pathway, CCM3 promotes proper cell growth and differentiation. Defects in the gene encoding CCM3 may be related to cerebral cavernous malformations 3 (CCM3), a disease characterized by vascular anomalies found in the central nervous system that can cause stroke, seizures and focal hemorrhages. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CCM3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 3-191 mapping within an internal region of CCM3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 3-191 mapping within an internal region of CCM3 of human origin |
| Entrez Gene | 11235 |
|---|
| Application Notes | recommended for detection of CCM3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
