| Product Name | ANKRD15 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 301-600 mapping within an internal region of ANKRD15 of human origin |
| Modification Notes | Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD15 (ankyrin repeat domain 15), also known as KANK1 (KN motif and ankyrin repeat domain-containing protein 1) or kidney ankyrin repeat-containing protein, is a 1,352 amino acid protein that contains at least twelve exons and five ANK repeats. Encoded by a gene that maps to human chromosome 9p24.3, ANKRD15 localizes to cytoplasm and may function as a tumor suppressor for renal cell carcinoma. ANKRD15 is ubiquitously expressed, with high expression in heart, prostate and ovary. However, ANKRD15 is not expressed in peripheral blood leukocytes. ANKRD15 defects are linked to cerebral palsy spastic quadriplegic type 2 (CPSQ2), a non-progressive disorder of movement or posture resulting from defects in the developing central nervous system. ANKRD15 deletion is also linked to parent-of-origin-dependent inheritance of familial cerebral palsy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ANKRD15 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 301-600 mapping within an internal region of ANKRD15 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 301-600 mapping within an internal region of ANKRD15 of human origin |
| Application Notes | recommended for detection of ANKRD15 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
