| Product Name | nephrocystin-3 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of nephrocystin-3 of human origin |
| Modification Notes | The nephrocystin proteins comprise a family of five enzymes that commonly interact with p130Cas (BCAR1), proline-rich tyrosine kinases, calmodulin, and tensin, indicating that these proteins may participate in a common signaling pathway. The NPHP3 gene encodes Nephrocystin-3, a protein that interacts with nephrocystin and may play a role in renal tubular function and development. Nephrocystin-3 contains a tubulin-tyrosine ligase (TTL) domain, a coiled-coil (CC) domain, and a tetratrico peptide repeat (TPR) domain. It is expressed widely at a low level, specifically in tissues such as the heart, placenta, liver, skeletal muscle, kidney and pancreas. In the brain and lung, Nephrocystin-3 is expressed at a very low level. Mutations in NPHP3 may cause nephronophthisis type 3, a recessive disorder affecting adolescents characterized by sclerosing tubulointerstitial nephropathy, alterations of tubular basement membranes, tubular atrophy and dilatation, and renal cyst development primarily at the corticomedullary junction. These symptoms lead to chronic renal failure in affected individuals.° |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of nephrocystin-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of nephrocystin-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of nephrocystin-3 of human origin |
| Entrez Gene | 27031 |
|---|
| Application Notes | recommended for detection of nephrocystin-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
