| Product Name | DOC4 Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 2515-2564 mapping within a C-terminal extracellular domain of DOC4 of human origin |
| Modification Notes | DOC4 is a mammalian ortholog of a Drosophila gene, Tenm/Odz, which is implicated in the patterning of the early fly embryo (1). Doc 4, for downstream of CHOP, is induced in response to stress and participates in CHOP/GADD153 signaling pathway (2). Doc 4 is a secreted protein that is expressed at high levels in certain cell types, while CHOP is a small nuclear protein that dimerizes avidly with members of the C/EBP family of transcription factor and is also induced in response to stress (3). The N-terminus peptide sequence of Doc 4 is identical to a novel portion of heregulin, which is in fact formed from a rare gene chromosomal translocation event between DOC4 and the heregulin gene HGL (4). Doc 4 (also designated Odz4) and several other mammalian homologs of Drosophila Tenm/Odz, mouse Odz3 and Odz2, all contain a putative signal peptide, eight EGF-like repeats, and a putative transmembrane domain followed by a 1800-amino-acid stretch having unique sequence patterns from other proteins outside this family (5). The mouse genes Odz3 and Doc 4/Odz4 exhibit partially overlapping, but clearly distinct, embryonic expression patterns, and Odz2 is predominantly expressed in the nervous system (6). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DOC4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 2515-2564 mapping within a C-terminal extracellular domain of DOC4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 2515-2564 mapping within a C-terminal extracellular domain of DOC4 of human origin |
| Application Notes | recommended for detection of DOC4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
