| Modification Notes |
CLIC4 (chloride intracellular channel 4), also known as H1, huH1, p64H1, CLIC4L or MTCLIC, is a 253 amino acid single-pass membrane protein that localizes to both nucleus and cytoplasm and contains one GST C-terminal domain. Expressed in placenta, heart and skeletal muscle, as well as in epithelial cells from kidney, colon and esophageal tissue, CLIC4 functions as a monomer that is able to form selective ion channels in target proteins, thereby facilitating the transport of chloride and other ions. CLIC5 (chloride intracellular channel 5) functions in both soluble and integral membrane forms and associates with actin-based cytoskeletal structures, suggesting involvement in their assembly and maintenance. In addition, CLIC5 may play an important role in inner ear function localizing to the stereocilia and possibly associating with Radixin. CLIC6 (chloride intracellular channel 6) is believed to play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport. The CLIC6 gene is a rare example of large-scale segmental paralogy in which a large (approximately 500 kb) segment on human chromosome (HC) 21 (21q22) is triplicated on HC 1 and HC 6. CLIC6 is also known to interact with dopamine receptors DRD2, DRD3 and DRD4. CLIC6 is primarily expressed in the cytoplasm, however, upon chloride ion efflux from the cell, CLIC6 is translocated to the plasma membrane. CLIC6 has been identified in brain, placenta, pancreas and liver. |
