Application
Western blot analysis of A1Up expression in HeLa (A), K-562 (B), IMR-32 (C) and SH-SY-5Y (D) nuclear extracts.| Product Name | A1Up Antibody (T-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of A1Up of human origin |
| Modification Notes | A1Up (Ataxin-1 ubiquitin-like-interacting protein), also known as UBQLN4 (ubiquilin 4), C1orf6 or UBIN, is a 601 amino acid protein that localizes to both the cytoplasm and the nucleus and is thought to associate with the endoplasmic reticulum (ER). Expressed at high levels in kidney, pancreas, heart, brain and skeletal muscle and at lower levels in liver, lung and placenta, A1Up functions as a homodimer that binds to signal sequences on proteins that are targeted to the ER. Additionally, A1Up is thought to link Ataxin-1 with ubiquitin/proteasome pathways, possibly assisting in the Ataxin-1-associated formation of multimeric protein complexes within the nucleus. A1Up contains one ubiquitin-like domain and one UBA domain and may be phosphorylated in response to DNA damage. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of A1Up of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of A1Up of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of A1Up of human origin |
| Entrez Gene | 56893 |
|---|
Application
Western blot analysis of A1Up expression in HeLa (A), K-562 (B), IMR-32 (C) and SH-SY-5Y (D) nuclear extracts.| Application Notes | recommended for detection of A1Up of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
