| Product Name | p-ALK Antibody (Tyr 1586) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Tyr 1586 of ALK of human origin |
| Modification | Phosphoralated |
| Modification Notes | LTK, Ros and ALK have been identified as receptor tyrosine kinases having sequence similarity to the insulin receptor subfamily of kinases. LTK (leukocyte tyrosine kinase) is expressed in murine B lymphocyte precursors and has also been found in forebrain neurons. The c-Ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development. ALK (anaplastic lymphoma kinase) is a 1630 amino acid protein that is normally highly expressed, specifically in the nervous system. A truncated form containing the catalytic domian of ALK is expressed as the result of a translocation occurring in many non-Hodgkin’s lymphomas. ALK phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Tyr 1586 phosphorylated ALK of human origin and correspondingly phosphorylated Tyr 1582 of mouse origin of m and h origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Tyr 1586 of ALK of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Tyr 1586 of ALK of human origin |
| Entrez Gene | 238 |
|---|
| Application Notes | recommended for detection of Tyr 1586 phosphorylated ALK of human origin and correspondingly phosphorylated Tyr 1582 of mouse origin of m and h origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
