Application
Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.| Product Name | POMC Antibody (FL-267) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-267 representing full length of POMC of human origin |
| Modification Notes | POMC (pro-opiomelanocortin), also known as corticotropin-lipotropin, is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific post-translational processing by prohormone convertases. POMC is cleaved into ten hormone chains named NPP, ©-MSH, ACTH, å-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin ∫, Lipotropin ©, ∫-MSH, ∫ endorphin and Met-enkephalin. The processed active peptide ACTH stimulates the release of cortisol by the adrenal glands while ©-MSH stimulates adrenal steroidogenesis. The active peptides ∫-endorphin and Met-enkephalin are both opioid neurotransmitters. Defects in the gene that encodes POMC are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency. Mutations in the POMC gene have also been linked to susceptibility to obesity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of POMC and all processed active peptides of mouse, rat and human origin by WB, IP, IF and ELISA may cross-react with proenkephalin A, proenkephalin B and their similar processed active peptides: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-267 representing full length of POMC of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-267 representing full length of POMC of human origin |
| Entrez Gene | 5443 |
|---|
Application
Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.| Application Notes | recommended for detection of POMC and all processed active peptides of mouse, rat and human origin by WB, IP, IF and ELISA may cross-react with proenkephalin A, proenkephalin B and their similar processed active peptides: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
