| Product Name | NPY1-R Antibody (H-91) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 181-271 mapping within an internal region of NPY1-R of human origin |
| Modification Notes | The NPY1R gene, located on human chromosome 4q32, encodes a 384 amino acid protein, NPY1-R (also designated Neuropeptide Y receptor Y1). NPY1-R is a member of the G-protein-coupled receptor superfamily, and like other members has seven putative transmembrane domains (1). However, NPY1-R gene consists of three exons, unlike the contiguous structure of other G-protein-coupled receptor genes. NPY1-R is expressed in the postsynaptic membrane of spleen, small intestine, kidney, testis, placenta, aortic smooth muscle, and throughout the central nervous system. NPY1-R associates with Neuropeptide Y, unphosphorylated Peptide YY (PYY) and particularly strongly with phosphorolated PYY. Depending on the cell type, NPY1-R couples with different G proteins, which act as second messengers. NPY1-R activation is necessary and sufficient for the release of substance P, a pain neurotransmitter, and the initiation of neurogenic inflammation. NPY1-R stimulates feeding behaviors, through an interaction with NPY. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NPY1-R of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 181-271 mapping within an internal region of NPY1-R of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 181-271 mapping within an internal region of NPY1-R of human origin |
| Entrez Gene | 4886 |
|---|
| Application Notes | recommended for detection of NPY1-R of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
