TRAPPC4 (trafficking protein particle complex 4), also known as SBDN, TRS23, PTD009, CGI-104, HSPC172 (hematopoietic stem/progenitor cell protein 172) or SYNBINDIN, is a postsynaptic protein belonging to the TRAPPC4 subfamily of the TRAPP small subunits family of proteins. Expressed in neurons and localizing to the Golgi apparatus, TRAPPC4 is believed to be involved in vesicular transport from the endoplasmic reticulum (ER) to the Golgi, functioning as a component of the multisubunit transport protein particle (TRAPP) complex. Similar to other proteins involved in vesicular transport or synaptic function, TRAPPC4 contains a nonclassical PDZ domain, a TRAPPC1-like domain and a C-terminus that is similar to a short segment of RyR. Via its nonclassical PDZ domain, TRAPPC4 binds to the C-terminal EFYA motif of Syndecan-2, suggesting that TRAPPC4 may play an important role in dendritic spine morphogenesis through membrane-trafficking.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of TRAPPC4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 1-145 mapping at the N-terminus of TRAPPC4 of human origin
Tissue Specificity
epitope corresponding to amino acids 1-145 mapping at the N-terminus of TRAPPC4 of human origin
Western blot analysis of TRAPPC4 expression in non-transfected: (A) and mouse TRAPPC4 transfected: (B) 293T whole cell lysates.
Application Notes
recommended for detection of TRAPPC4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.