| Modification Notes |
The Major facilitator superfamily (MFS) is a large group of secondary transporters that includes uniporters, symporters and antiporters. MFS proteins transport a variety of substrates across membranes, such as sugar phosphates, drugs, neurotransmitters, amino acids, ions, peptides and nucleosides. As a member of the MFS superfamily, LST-3TM12 (liver-specific organic anion transporter 3TM12) is a 640 amino acid protein that contains a kazal-type serine protease inhibitor domain, which is usually detected in SLC21 family members and may regulate the specificity of anion uptake. The LST-3TM12 gene is located within a region on chromosome 12 that has been associated with hepatic transporter reduced affinity for bilirubin. |