| Modification Notes |
Vacuolar sorting proteins (VPSs) are required for proper trafficking of endocytic and biosynthetic proteins to the vacuole and play an important role in the budding process of cells. VPS29 (vacuolar protein sorting 29 homolog), also known as DC7, DC15 or PEP11, is a 182 amino acid peripheral membrane protein that localizes to both the cytoplasm and to the endosomal membrane and exists as a component of a large multimeric retromer complex. VPS29 is expressed at high levels in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain, where it plays an important role in retrograde transport of proteins from endosomes to the trans-Golgi network. Multiple isoforms of VPS29 exist due to alternative splicing events. |