Application
Western blot analysis of DDX17 expression in Jurkat whole cell lysate.| Product Name | DDX17 Antibody (H-157) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 485-641 mapping near the C-terminus of DDX17 of human origin |
| Modification Notes | Characterized by the conserved motif Asp-Glu-Ala-Asp, DEAD box proteins are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure. Specifically, DEAD box proteins are involved in translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX17 (DEAD box protein 17), also designated p72, is highly homologous to DDX5 (p68). DDX17 and DDX5 have been implicated in growth regulation by acting as transcriptional co-regulators for several transcription factors, including ERå, p53, MyoD and Runx2. Impairment of DDX17 may affect early brain development and can lead to Down Syndrome. Alternatively, up-regulation of DDX17 and DDX5 directly contributes to colon cancer, suggesting that DDX17 may be a useful therapeutic target to combat colon cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DDX17 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 485-641 mapping near the C-terminus of DDX17 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 485-641 mapping near the C-terminus of DDX17 of human origin |
| Entrez Gene | 10521 |
|---|
Application
Western blot analysis of DDX17 expression in Jurkat whole cell lysate.| Application Notes | recommended for detection of DDX17 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
