Application
Western blot analysis of FUCA2 expression in non-transfected (A) and human FUCA2 transfected (B) 293 whole cell lysates.Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.| Product Name | FUCA2 Antibody (V-23) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | FUCA2 (fucosidase, alpha-L- 2, plasma), also known as alpha-L-fucosidase 2, is a 467 amino acid secreted protein that exists as a homotetramer and localizes specifically to plasma (unlike FUCA1 which is specific to tissues). Belonging to the glycosyl hydrolase family, FUCA2 functions to catalyze the H2O-dependent conversion of an alpha-L-fucoside to an alcohol. Specifically, FUCA2 hydrolyzes the alpha-1,6-linked fucose that is joined to the N-acetylglucosamine residue of target glycoproteins, thereby yielding L-fucose and alcohol. As FUCA2 is responsible for regulating the amount of alpha-L-fucosidase within plasma, defects in the gene encoding FUCA2 that cause a loss of catalytic activity may lead to a decrease in alpha-L-fucosidase levels and, ultimately, fucosidosis. Fucosidosis is a very rare autosomal recessive glycoprotein storage disease that is characterized by organomegaly, mental retardation and twisted blood vessels. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of FUCA2 of human origin by WB IP IF IHC(P) and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of FUCA2 of human origin by WB, IP, IF, IHC(P) and ELISA |
| Entrez Gene | 2519 |
|---|
Application
Western blot analysis of FUCA2 expression in non-transfected (A) and human FUCA2 transfected (B) 293 whole cell lysates.
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
