Application
Western blot analysis of MARK4 expression in Jurkat whole cell lysate.| Product Name | MARK4 Antibody (H-125) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. The serine/threonine (Ser/Thr) protein kinases are a group of proteins that are intimately involved in this process. MARK4 (MAP/microtubule affinity-regulating kinase 4), also known as MARKL1 or KIAA1860, is a 752 amino acid protein that contains one UBA domain, one protein kinase domain and one kinase-associated domain and belongs to the Ser/Thr protein kinase family. Expressed ubiquitously as two alternatively spliced isoforms, one of which is brain-specific, MARK4 uses ATP to catalyze the phosphorylation of target proteins and is thought to be involved in cell growth. MARK4 is upregulated in hepatocellular carcinoma cells, suggesting a role for MARK4 in tumorigenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MARK4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 628-752 mapping at the C-terminus of MARK4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 628-752 mapping at the C-terminus of MARK4 of human origin |
| Entrez Gene | 57787 |
|---|
Application
Western blot analysis of MARK4 expression in Jurkat whole cell lysate.| Application Notes | recommended for detection of MARK4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
