Application
Western blot analysis of ARH expression in H460 whole cell lysate.Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.| Product Name | ARH Antibody (E-22) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Autosomal recessive hypercholesterolemia protein (ARH, low density lipoprotein (LDL) receptor adaptor protein) is a cytosolic adaptor that couples LDLR to endocytic machinery (1,2). ARH couples to the internalization motif of the LDL receptor-FXNPXY, through an N-terminal phosphotyrosine-binding (PTB) domain and binds soluble clathrin trimers and clathrin adaptors (3,4). ARH is present at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes (5). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFIHCELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of ARH of human origin by WB IF IHC(P) and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of ARH of human origin by WB, IF, IHC(P) and ELISA |
| Entrez Gene | 26119 |
|---|
Application
Western blot analysis of ARH expression in H460 whole cell lysate.
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
