| Modification Notes |
The interleukins (ILs) are a broad family of well characterized cytokines, primarily of hematopoietic cell origin, and are secreted by immune cells (mainly macrophages, B-cells or T-cells) that regulate a wide range of immune system functions. The specific functions of different interleukins vary from the regulation of inflammatory and immune responses to the regulation of other interleukins. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. IL-17RC (interleukin 17 receptor C) is a 791 amino acid single-pass type I transmembrane protein that may function as a receptor for IL-17. Existing as multiple alternatively spliced isoforms, IL-17RC is expressed in heart, brain, intestine, liver, kidney, lung, muscle, placenta and prostate and is encoded by a gene which maps to human chromosome 3. |
