Application
Western blot analysis of REXO2 expression in non-transfected: (A) and mouse REXO2 transfected: (B) 293T whole cell lysates.| Product Name | REXO2 Antibody (H-138) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Proper DNA and RNA metabolism requires nucleases which function in DNA replication, recombination and repair, as well as in RNA processing and degradation events. REXO2 (RNA exonuclease 2), also called RFN or SFN, is the human homolog of the E. coli exoribonuclease Orn. Functioning as a 3’-to-5’ exoribonuclease, REXO2 degrades single-stranded RNA or DNA and, based on its similarity with Orn, may be involved in cellular responses to DNA-damaging agents. Additionally, REXO2 is implicated in cellular nucleotide recycling and can use manganese as a cofactor. Two isoforms of REXO2 exist due to alternative splicing events. Isoform 1 is localized to the mitochondria, while isoform 2 is localized to the nucleus. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of REXO2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 39-176 mapping within an internal region of REXO2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 39-176 mapping within an internal region of REXO2 of human origin |
| Entrez Gene | 25996 |
|---|
Application
Western blot analysis of REXO2 expression in non-transfected: (A) and mouse REXO2 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of REXO2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
